In 2007, Saran starred in Sivaji: The Boss, the highest grossing Tamil film at that time. She also gained critical acclaim for her role in the 2007 Bollywood film Awarapan. In 2008, Saran played the lead role in her first English film, the American-Indian co-production The Other End of the Line. Her following projects included popular films such as Kanthaswamy (2009) in Tamil, and Pokkiri Raja (2010) in Malayalam, her roles in which have established her as one of the leading actresses in the South Indian film industries.
Apart from her work in films, Saran has been the brand ambassador for several stores across India, endorsing beauty and health products. Among other activities, she has volunteered for a number of charity organisations, and in 2011 opened a spa employing visually challenged people.